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Taking medication on an empty stomach can be a sensitive issue, especially when it comes to over-the-counter drugs like Advil PM and Diphenhydramine Hydrochloride. Many of us might have some questions on whether taking these medicines on an empty stomach has any adverse effects, or is it okay to take them on an empty stomach. There are times when we need to take medication, but our stomach is empty, either because we have not eaten for a while, or it’s early morning, and we need the medicine. If you are in this situation, the question “Can I take Advil PM on an empty stomach?” might be popping up in your mind. The answer to this question is yes, you can take Advil PM on an empty stomach. However, it’s always better if you take Advil PM after a meal. Advil PM is a pain reliever that is composed of two active ingredients - ibuprofen and Diphenhydramine Hydrochloride. Ibuprofen is a Non-Steroidal Anti-Inflammatory Drug (NSAID), while Diphenhydramine Hydrochloride is an antihistamine that helps relieve allergy symptoms and helps you sleep. When you take Advil PM, it is absorbed in your bloodstream, and then your liver metabolizes it, reducing its effect. Studies have shown that taking medication after a meal can slow down the speed of absorption, and this can lead to a more prolonged effect of the medicine. This is because food can slow down the gastric emptying rate, and this leads to an increase in the time it takes for Advil to reach the small intestines, where absorption occurs. Now, let’s consider the question: “Can you take Advil with Diphenhydramine Hydrochloride on an empty stomach?” The answer to this question is yes. You can take Advil with Diphenhydramine Hydrochloride with or without food. However, taking it with food might reduce the risk of stomach irritation. It’s always crucial to read the instructions on the label and consult your doctor before taking any medication, especially if you have a pre-existing medical condition or are taking other medications. In conclusion, it is okay to take Advil PM and Diphenhydramine Hydrochloride on an empty stomach, though it’s always better to take them after a meal. However, caution must be taken to avoid stomach irritation, and as a reminder, it’s always crucial to consult your doctor before taking any medication.

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